In [3]:
import numpy as np
import pandas as pd
import matplotlib.pyplot as plt
import seaborn as sns
import statistics
from sklearn.linear_model import LogisticRegression
from sklearn.feature_selection import RFECV
from sklearn.metrics import (
mean_squared_error, r2_score, accuracy_score, auc, roc_curve, roc_auc_score, confusion_matrix
)
from sklearn.model_selection import (
train_test_split,
StratifiedKFold,
GridSearchCV, RandomizedSearchCV
)
Loading Data¶
In [11]:
# 读取数据
data = pd.read_csv('./data_processed/data_first_record_with_commorbidities.csv', index_col=0)
print(f'INFO: Data shape: {data.shape}')
# 填充缺失值
print(f'INFO: Has Missing Value (before): {data.isna().any().any()}')
data.fillna(data.mean(), inplace=True)
print(f'INFO: Has Missing Value (after): {data.isna().any().any()}')
# 查看 LOS 的情况
los_mean = data.los.mean()
print(f"\nAverage days of LOS: {los_mean:.2f}±{data.los.std():.2f} days")
print(
f"Quantile 0.20 0.50 0.80\n"
f" {data.los.quantile(0.20):.2f} {data.los.quantile(0.50):.2f} {data.los.quantile(0.80):.2f}"
)
INFO: Data shape: (652, 34) INFO: Has Missing Value (before): True INFO: Has Missing Value (after): False Average days of LOS: 3.29±4.35 days Quantile 0.20 0.50 0.80 1.05 1.91 4.12
In [12]:
data.columns
Out[12]:
Index(['los', 'gender', 'age', 'heart_rate', 'respiratory_rate', 'hematocrit', 'rdw', 'platelet', 'mcv', 'mch', 'hemoglobin', 'die_in_icu', 'uc_only', 'cd_only', 'language_ENGLISH', 'marital_status_MARRIED', 'insurance_Medicare', 'insurance_Other', 'icu_count', 'Diabetes mellitus', 'Hyposmolality and/or hyponatremia', 'Thrombocytopenia', 'Tobacco use disorder', 'Congestive heart failure', 'Other finger(s) amputation status', 'Acute respiratory failure', 'Other specified intestinal obstruction', 'Acute kidney failure', 'Urinary tract infection', 'Tachycardia', 'Severe sepsis', 'Anemia', 'Essential (primary) hypertension', 'Personal history of tobacco use'], dtype='object')
In [13]:
df = (
data
# .loc[data.die_in_icu == 1, :]
.drop(columns=['die_in_icu'])
.assign(los = (data.los >= data.los.mean()).astype('int32'))
)
df
Out[13]:
los | gender | age | heart_rate | respiratory_rate | hematocrit | rdw | platelet | mcv | mch | ... | Other finger(s) amputation status | Acute respiratory failure | Other specified intestinal obstruction | Acute kidney failure | Urinary tract infection | Tachycardia | Severe sepsis | Anemia | Essential (primary) hypertension | Personal history of tobacco use | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 1 | 0.684717 | 0.28750 | 0.32 | 0.425234 | 0.484848 | 0.127773 | 0.770492 | 0.742015 | ... | 0.000000 | 0.000000 | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 0.000000 | 0.00000 | 0.00000 | 0.000000 |
1 | 0 | 1 | 0.833860 | 0.28750 | 0.38 | 0.474299 | 0.579545 | 0.164153 | 0.672131 | 0.680590 | ... | 0.000000 | 0.000000 | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 0.000000 | 0.00000 | 0.00000 | 0.000000 |
2 | 1 | 1 | 0.514176 | 0.41250 | 0.74 | 0.635514 | 0.640152 | 0.007986 | 0.762295 | 0.754300 | ... | 1.000000 | 1.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 1.000000 | 0.00000 | 0.00000 | 0.000000 |
3 | 1 | 1 | 0.393528 | 0.40625 | 0.40 | 0.355140 | 0.583333 | 0.062112 | 0.704918 | 0.761671 | ... | 0.000000 | 0.000000 | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 0.000000 | 0.00000 | 0.00000 | 1.000000 |
4 | 0 | 0 | 0.464178 | 0.11875 | 0.34 | 0.436916 | 0.481061 | 0.236912 | 0.754098 | 0.783784 | ... | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.00000 | 0.00000 | 0.000000 |
... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... | ... |
647 | 0 | 0 | 0.741280 | 0.26250 | 0.42 | 0.394860 | 0.522727 | 0.192547 | 0.778689 | 0.764128 | ... | 0.000000 | 0.000000 | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 0.000000 | 0.00000 | 0.00000 | 1.000000 |
648 | 0 | 0 | 0.327277 | 0.47500 | 0.32 | 0.292056 | 0.731061 | 0.319432 | 0.614754 | 0.555283 | ... | 0.125714 | 0.179048 | 0.074286 | 0.377143 | 0.262857 | 0.078095 | 0.158095 | 0.04381 | 0.07619 | 0.293333 |
649 | 0 | 0 | 1.000000 | 0.42500 | 0.34 | 0.801402 | 0.564394 | 0.206744 | 0.827869 | 0.754300 | ... | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 1.000000 | 0.000000 | 1.000000 | 0.00000 | 0.00000 | 0.000000 |
650 | 1 | 0 | 0.498847 | 0.41250 | 0.42 | 0.296729 | 0.564394 | 0.052351 | 0.762295 | 0.796069 | ... | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 0.00000 | 0.00000 | 1.000000 |
651 | 1 | 1 | 0.453674 | 0.33750 | 0.58 | 0.605140 | 0.530303 | 0.209406 | 0.844262 | 0.852580 | ... | 0.000000 | 1.000000 | 0.000000 | 1.000000 | 0.000000 | 0.000000 | 1.000000 | 0.00000 | 0.00000 | 0.000000 |
652 rows × 33 columns
In [19]:
X = df.loc[:, df.columns != 'los']
y = df.loc[:, df.columns == 'los']
X_train, X_test, y_train, y_test = train_test_split(X, y, test_size=0.3, random_state=84)
In [20]:
model = LogisticRegression(max_iter=1000)
model.fit(X_train, np.array(y_train).reshape(-1))
Out[20]:
LogisticRegression(max_iter=1000)In a Jupyter environment, please rerun this cell to show the HTML representation or trust the notebook.
On GitHub, the HTML representation is unable to render, please try loading this page with nbviewer.org.
LogisticRegression(max_iter=1000)
In [21]:
# res = pd.DataFrame(model.coef_.reshape(-1), index=X.columns, columns=['Coefficient'])
y_pred = model.predict(X_test)
accuracy = accuracy_score(y_test, y_pred)
print(f"Accuracy: {accuracy * 100.0}")
cm = confusion_matrix(y_test, y_pred)
print(cm)
Accuracy: 72.44897959183673 [[133 7] [ 47 9]]
In [22]:
y_scores = model.predict_proba(X_test)[:, 1]
fpr, tpr, thresholds = roc_curve(y_test, y_scores)
roc_auc = auc(fpr, tpr)
plt.figure(figsize=(5, 5), dpi=300)
plt.plot(fpr,
tpr,
color='darkorange',
lw=2,
label=f'ROC curve (area = {roc_auc:.2f})')
plt.fill_between(fpr, tpr, color='darkorange', alpha=0.2) # alpha 参数控制填充颜色的透明度
plt.plot([0, 1], [0, 1], color='navy', lw=2, linestyle='--')
plt.xlim([0.0, 1.0])
plt.ylim([0.0, 1.05])
plt.xlabel('False Positive Rate')
plt.ylabel('True Positive Rate')
plt.legend(loc="lower right")
plt.show()
In [23]:
for random_seed in range(0, 1000):
X_train, X_test, y_train, y_test = train_test_split(X, y, test_size=0.2, random_state=random_seed)
model = LogisticRegression(max_iter=1000)
model.fit(X_train, np.array(y_train).reshape(-1))
y_pred = model.predict(X_test)
accuracy = accuracy_score(y_test, y_pred)
y_scores = model.predict_proba(X_test)[:, 1]
fpr, tpr, thresholds = roc_curve(y_test, y_scores)
roc_auc = auc(fpr, tpr)
print(f"Seed: {random_seed} acc: {accuracy * 100.0} auc: {roc_auc}")
Seed: 0 acc: 78.62595419847328 auc: 0.6531440162271804 Seed: 1 acc: 64.8854961832061 auc: 0.6199059561128527 Seed: 2 acc: 76.33587786259542 auc: 0.6026592455163884 Seed: 3 acc: 75.57251908396947 auc: 0.6883116883116882 Seed: 4 acc: 74.80916030534351 auc: 0.6303571428571428 Seed: 5 acc: 73.2824427480916 auc: 0.5850340136054422 Seed: 6 acc: 73.2824427480916 auc: 0.5411255411255411 Seed: 7 acc: 75.57251908396947 auc: 0.6485380116959064 Seed: 8 acc: 69.46564885496184 auc: 0.5857385398981324 Seed: 9 acc: 80.1526717557252 auc: 0.6148753894080997 Seed: 10 acc: 75.57251908396947 auc: 0.612280701754386 Seed: 11 acc: 72.51908396946564 auc: 0.6525166767738023 Seed: 12 acc: 77.09923664122137 auc: 0.6177358490566037 Seed: 13 acc: 73.2824427480916 auc: 0.5924551638837353 Seed: 14 acc: 74.80916030534351 auc: 0.5720470006184293 Seed: 15 acc: 70.99236641221374 auc: 0.6945054945054945 Seed: 16 acc: 81.67938931297711 auc: 0.7794729542302359 Seed: 17 acc: 75.57251908396947 auc: 0.7028862478777589 Seed: 18 acc: 67.93893129770993 auc: 0.5755494505494505 Seed: 19 acc: 70.22900763358778 auc: 0.5178372352285395 Seed: 20 acc: 76.33587786259542 auc: 0.6446331109763493 Seed: 21 acc: 69.46564885496184 auc: 0.5797619047619048 Seed: 22 acc: 70.99236641221374 auc: 0.5727424749163879 Seed: 23 acc: 70.99236641221374 auc: 0.6444444444444445 Seed: 24 acc: 68.70229007633588 auc: 0.6617336152219873 Seed: 25 acc: 73.2824427480916 auc: 0.6076923076923076 Seed: 26 acc: 76.33587786259542 auc: 0.48174442190669375 Seed: 27 acc: 70.22900763358778 auc: 0.5795454545454545 Seed: 28 acc: 76.33587786259542 auc: 0.7038539553752535 Seed: 29 acc: 67.93893129770993 auc: 0.6229096989966555 Seed: 30 acc: 72.51908396946564 auc: 0.6 Seed: 31 acc: 72.51908396946564 auc: 0.6536502546689305 Seed: 32 acc: 75.57251908396947 auc: 0.576774193548387 Seed: 33 acc: 67.93893129770993 auc: 0.6436597110754414 Seed: 34 acc: 70.99236641221374 auc: 0.5991949396204715 Seed: 35 acc: 66.41221374045801 auc: 0.6094168004280364 Seed: 36 acc: 78.62595419847328 auc: 0.6291035353535354 Seed: 37 acc: 77.86259541984732 auc: 0.6641935483870968 Seed: 38 acc: 77.09923664122137 auc: 0.6541935483870969 Seed: 39 acc: 72.51908396946564 auc: 0.5777777777777778 Seed: 40 acc: 70.22900763358778 auc: 0.5294642857142857 Seed: 41 acc: 77.86259541984732 auc: 0.6312916919345057 Seed: 42 acc: 71.7557251908397 auc: 0.5537634408602151 Seed: 43 acc: 74.04580152671755 auc: 0.7222541690626797 Seed: 44 acc: 69.46564885496184 auc: 0.6138211382113822 Seed: 45 acc: 82.44274809160305 auc: 0.6833333333333333 Seed: 46 acc: 74.80916030534351 auc: 0.6631291691934507 Seed: 47 acc: 73.2824427480916 auc: 0.6412541254125412 Seed: 48 acc: 69.46564885496184 auc: 0.5738930419781484 Seed: 49 acc: 74.04580152671755 auc: 0.6357323232323233 Seed: 50 acc: 75.57251908396947 auc: 0.5706488781079442 Seed: 51 acc: 73.2824427480916 auc: 0.5942995755003032 Seed: 52 acc: 70.99236641221374 auc: 0.5836870830806549 Seed: 53 acc: 71.7557251908397 auc: 0.564938684503902 Seed: 54 acc: 68.70229007633588 auc: 0.5997574287446937 Seed: 55 acc: 73.2824427480916 auc: 0.6499999999999999 Seed: 56 acc: 70.22900763358778 auc: 0.6855287569573284 Seed: 57 acc: 70.22900763358778 auc: 0.5269005847953216 Seed: 58 acc: 73.2824427480916 auc: 0.5091277890466531 Seed: 59 acc: 72.51908396946564 auc: 0.5961538461538461 Seed: 60 acc: 72.51908396946564 auc: 0.603586889301175 Seed: 61 acc: 69.46564885496184 auc: 0.5799892990904227 Seed: 62 acc: 77.86259541984732 auc: 0.6519102486355367 Seed: 63 acc: 77.86259541984732 auc: 0.6746513038204973 Seed: 64 acc: 72.51908396946564 auc: 0.693452380952381 Seed: 65 acc: 74.04580152671755 auc: 0.5732838589981447 Seed: 66 acc: 70.99236641221374 auc: 0.6511503477795613 Seed: 67 acc: 70.22900763358778 auc: 0.7578005115089513 Seed: 68 acc: 74.04580152671755 auc: 0.5410714285714286 Seed: 69 acc: 80.91603053435115 auc: 0.6419354838709677 Seed: 70 acc: 70.99236641221374 auc: 0.7085455574419921 Seed: 71 acc: 73.2824427480916 auc: 0.6356435643564357 Seed: 72 acc: 73.2824427480916 auc: 0.6228021978021979 Seed: 73 acc: 77.09923664122137 auc: 0.6873840445269016 Seed: 74 acc: 72.51908396946564 auc: 0.5609152752009895 Seed: 75 acc: 74.80916030534351 auc: 0.7537901758641601 Seed: 76 acc: 67.17557251908397 auc: 0.5315934065934066 Seed: 77 acc: 70.22900763358778 auc: 0.6479933110367894 Seed: 78 acc: 70.22900763358778 auc: 0.6514619883040936 Seed: 79 acc: 78.62595419847328 auc: 0.5975783475783476 Seed: 80 acc: 71.7557251908397 auc: 0.6069609507640068 Seed: 81 acc: 70.99236641221374 auc: 0.5633717404487568 Seed: 82 acc: 65.64885496183206 auc: 0.6424418604651163 Seed: 83 acc: 75.57251908396947 auc: 0.665483870967742 Seed: 84 acc: 67.93893129770993 auc: 0.5762273901808785 Seed: 85 acc: 68.70229007633588 auc: 0.5696095076400679 Seed: 86 acc: 82.44274809160305 auc: 0.6926638176638177 Seed: 87 acc: 75.57251908396947 auc: 0.6487096774193548 Seed: 88 acc: 71.7557251908397 auc: 0.5643274853801169 Seed: 89 acc: 74.80916030534351 auc: 0.5867986798679866 Seed: 90 acc: 70.99236641221374 auc: 0.5818428184281843 Seed: 91 acc: 73.2824427480916 auc: 0.5678550891316849 Seed: 92 acc: 70.99236641221374 auc: 0.6722527472527473 Seed: 93 acc: 74.04580152671755 auc: 0.6630247268545141 Seed: 94 acc: 71.7557251908397 auc: 0.6323857302118172 Seed: 95 acc: 76.33587786259542 auc: 0.6388888888888888 Seed: 96 acc: 74.80916030534351 auc: 0.7307449494949495 Seed: 97 acc: 71.7557251908397 auc: 0.6018799272286234 Seed: 98 acc: 74.80916030534351 auc: 0.6252274105518496 Seed: 99 acc: 76.33587786259542 auc: 0.48064516129032264 Seed: 100 acc: 70.99236641221374 auc: 0.5928126768534239 Seed: 101 acc: 77.86259541984732 auc: 0.722258064516129 Seed: 102 acc: 74.80916030534351 auc: 0.6273964131106988 Seed: 103 acc: 76.33587786259542 auc: 0.5454545454545454 Seed: 104 acc: 70.99236641221374 auc: 0.6828316610925306 Seed: 105 acc: 74.80916030534351 auc: 0.6776785714285715 Seed: 106 acc: 74.80916030534351 auc: 0.5976190476190476 Seed: 107 acc: 71.7557251908397 auc: 0.6283240568954855 Seed: 108 acc: 66.41221374045801 auc: 0.6248538011695907 Seed: 109 acc: 73.2824427480916 auc: 0.6571428571428571 Seed: 110 acc: 74.04580152671755 auc: 0.6802760207015527 Seed: 111 acc: 77.09923664122137 auc: 0.699443413729128 Seed: 112 acc: 65.64885496183206 auc: 0.6214285714285714 Seed: 113 acc: 69.46564885496184 auc: 0.6586409844836811 Seed: 114 acc: 69.46564885496184 auc: 0.6236786469344608 Seed: 115 acc: 70.22900763358778 auc: 0.5696095076400679 Seed: 116 acc: 73.2824427480916 auc: 0.6058290888511602 Seed: 117 acc: 77.86259541984732 auc: 0.6149181322013342 Seed: 118 acc: 74.04580152671755 auc: 0.654639175257732 Seed: 119 acc: 72.51908396946564 auc: 0.5561290322580645 Seed: 120 acc: 74.80916030534351 auc: 0.6027721433400948 Seed: 121 acc: 64.8854961832061 auc: 0.594224924012158 Seed: 122 acc: 71.7557251908397 auc: 0.6360544217687076 Seed: 123 acc: 67.93893129770993 auc: 0.6106465997770345 Seed: 124 acc: 67.93893129770993 auc: 0.540650406504065 Seed: 125 acc: 70.99236641221374 auc: 0.5782241014799154 Seed: 126 acc: 75.57251908396947 auc: 0.5419141914191419 Seed: 127 acc: 71.7557251908397 auc: 0.597741935483871 Seed: 128 acc: 74.80916030534351 auc: 0.6416009702850212 Seed: 129 acc: 70.99236641221374 auc: 0.640598044853364 Seed: 130 acc: 70.99236641221374 auc: 0.6287262872628726 Seed: 131 acc: 70.99236641221374 auc: 0.6603970741901777 Seed: 132 acc: 76.33587786259542 auc: 0.5818713450292398 Seed: 133 acc: 76.33587786259542 auc: 0.6726072607260726 Seed: 134 acc: 71.7557251908397 auc: 0.6088817549491707 Seed: 135 acc: 77.09923664122137 auc: 0.6929032258064517 Seed: 136 acc: 66.41221374045801 auc: 0.577324973876698 Seed: 137 acc: 76.33587786259542 auc: 0.6196660482374768 Seed: 138 acc: 70.22900763358778 auc: 0.61892177589852 Seed: 139 acc: 72.51908396946564 auc: 0.5848896434634975 Seed: 140 acc: 74.80916030534351 auc: 0.5760667903525046 Seed: 141 acc: 74.04580152671755 auc: 0.6209677419354839 Seed: 142 acc: 77.86259541984732 auc: 0.69 Seed: 143 acc: 71.7557251908397 auc: 0.5990379173740803 Seed: 144 acc: 68.70229007633588 auc: 0.6294926004228331 Seed: 145 acc: 76.33587786259542 auc: 0.694760101010101 Seed: 146 acc: 70.99236641221374 auc: 0.5188620902906618 Seed: 147 acc: 74.80916030534351 auc: 0.5644048303622772 Seed: 148 acc: 74.80916030534351 auc: 0.6058217101273499 Seed: 149 acc: 66.41221374045801 auc: 0.5184143222506394 Seed: 150 acc: 71.7557251908397 auc: 0.5260764099454215 Seed: 151 acc: 80.1526717557252 auc: 0.6274193548387097 Seed: 152 acc: 66.41221374045801 auc: 0.5699404761904762 Seed: 153 acc: 70.22900763358778 auc: 0.6422764227642276 Seed: 154 acc: 70.22900763358778 auc: 0.6617886178861789 Seed: 155 acc: 77.86259541984732 auc: 0.6480429292929294 Seed: 156 acc: 74.04580152671755 auc: 0.6105476673427992 Seed: 157 acc: 75.57251908396947 auc: 0.6604370327774582 Seed: 158 acc: 74.04580152671755 auc: 0.5865497076023392 Seed: 159 acc: 68.70229007633588 auc: 0.6880877742946708 Seed: 160 acc: 70.22900763358778 auc: 0.5770465489566613 Seed: 161 acc: 74.80916030534351 auc: 0.6008928571428571 Seed: 162 acc: 67.17557251908397 auc: 0.5957446808510639 Seed: 163 acc: 73.2824427480916 auc: 0.6 Seed: 164 acc: 64.12213740458014 auc: 0.506838905775076 Seed: 165 acc: 67.17557251908397 auc: 0.634974533106961 Seed: 166 acc: 73.2824427480916 auc: 0.5651910248635537 Seed: 167 acc: 72.51908396946564 auc: 0.539766081871345 Seed: 168 acc: 71.7557251908397 auc: 0.5491661874640599 Seed: 169 acc: 71.7557251908397 auc: 0.6487426431246656 Seed: 170 acc: 73.2824427480916 auc: 0.5084249084249084 Seed: 171 acc: 71.7557251908397 auc: 0.621909143185739 Seed: 172 acc: 75.57251908396947 auc: 0.7023809523809524 Seed: 173 acc: 75.57251908396947 auc: 0.5862708719851577 Seed: 174 acc: 71.7557251908397 auc: 0.6476190476190476 Seed: 175 acc: 72.51908396946564 auc: 0.5928126768534239 Seed: 176 acc: 73.2824427480916 auc: 0.5047619047619047 Seed: 177 acc: 67.17557251908397 auc: 0.6046013911182451 Seed: 178 acc: 74.04580152671755 auc: 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